Utility of Salivary and Serum Auto-antibodies against Tumor Biomarkers HER2 and MUC1 in Breast Cancer Screening

Breast cancer is the most common cancer and considered as the second cause of mortality in woman (Begum et al., 2012). Early detection of this pathology is very useful way to decrease it (Tjemslanda and Soreide, 2004). Currently, mammography stills the gold standard test for breast cancer screening (Tarhan et al., 2014). However, breast cancer may be hard to detect in some women with dense breast tissues (Tarhan et al., 2013; Tarhan et al., 2014). Consequently, circulating tumors biomarkers attracted more attention to detect cancer at an early stage, in diagnosis, treatment and metastasis prediction (Porika et al., 2010; Maric et al., 2011). In breast cancer, many biomarkers are used for this purpose such as HER2 (human epidermal growth factor receptor) and CA 15-3 (Cancer Antigen) (Maric et al., 2011; Moazzezy et al., 2014). In fact, HER2 is overexpressed in 20%-25% of breast cancers, gene amplification has been observed in